Serum Concentrations of Penicillin Following Administration of Crystalline Procaine Penicillin G in Aqueous Suspension

Summary1. Administration of 300,000 units of crystalline procaine penicillin G in aqueous suspension produced demonstrable serum penicillin concentrations at 12 hours after administration in all subjects and at 24 hours after injection in 92% of subjects studied.2. Administration of 600,000 units of this material produced demonstrable serum penicillin concentrations 24 hours after injection in all subjects.3. Similar patterns of serum penicillin concentrations were obtained for both the oil and the aqueous suspensions of procaine penicillin G although slightly lower values were generally observed with the aqueous suspension.4. Ease of administration and absence of untoward: local or systemic reaction were uniformly observed with the administration of procaine penicillin G in aqueous suspension.