Update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol: statistical analysis plan for a prospective, multicenter, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial.

Christopher J. Lindsell,Anna McGlothlin,Samuel K. Nwosu,Todd W. Rice,Alex Hall,Gordon R. Bernard,Laurence W. Busse,E. Wesley Ely,Alpha A. Fowler,David F. Gaieski,Jeremiah S. Hinson,Michael H. Hooper,James C. Jackson,Gabor D. Kelen,Mark Levine,Greg S. Martin,Richard E. Rothman,Jonathan E. Sevransky,Kert Viele,David W. Wright,David N. Hager

Update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol: statistical analysis plan for a prospective, multicenter, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial.

2019

Background Observational research suggests that combined therapy with Vitamin C, thiamine and hydrocortisone may reduce mortality in patients with septic shock.

Keywords:

Placebo
Observational study
Sepsis
Septic shock
Sample size determination
Clinical trial
Hydrocortisone
Intensive care medicine
Medicine
Internal medicine
Thiamine

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