880 The Resistance of S. Aureus to Antibacterials in Children

Background and Aims Clinical strains of S. aureus are one of the most widely spread microorganisms, causing nosocomial purulent infections in pediatric anesthesiology practice. Treatment of infectious diseases caused by Staphylococcus is a difficult task in conditions of developing resistance to antibiotics. Methods Our research work is dedicated to the problem of antibiotic resistance of S. aureus clinical strains, obtained from children with purulent-inflammatory diseases. The Staphylococcus strains’ sensitivity to the spectrum of antibiotics, nowadays widely used in clinical practice, was studied by means of disc-diffusion method. Results The results of the study show high resistance of S. aureus to antibiotics of penicillin (26.79–53.57%). About 42.86% of strains were resistant to oxacillin. It proves the presence of methicillin-resistant strains of S. aureus in children with purulent diseases. S. aureus had also low sensitivity to ureidopenicillins, aminopenicillins, carbenicillins. As for aminopennicilin with clavulan acid only 1.78% of strains were resistant. The 1st (cafazolin-83.93%) and the 3rd generation of cephalosporins (ceftriaxone-89.28%, ceftazidim-80.36%) had high activity against S. aureus. Obtained isolates of S. aureus were sensitive to meropenem (87.5%) aminoglycosides (14.29–89.29%). 67.86% of strains were sensitive to rifampicin. But only in 41.07% of cases S. aureus was sensitive to vancomycin. Doxycycline was effective in 57.14%. Conclusions In our study S. aureus strains obtained from children purulent-infectious diseases have high sensitivity to aminopenicillin with clavulan acid, meropenem, some cephalosporins, gentamycin. Among clinical strains of S. aureus we found methicillin- and even vancomycin-resistant microorganisms.