Effects of Olmesartan, an Angiotensin II Receptor Blocker, on Mechanically-Modulated Genes in Cardiac Myocytes

Background: Angiotensin II plays an important role in cardiac hypertrophy or remodeling. Angiotensin II receptor blockers (ARB) are clinically useful for the treatment of hypertension and heart failure. However, the molecular effects of ARB in the mechanically-stressed myocardium have not been completely defined. We investigated the effects of ARB on mechanically-modulated genes in cardiac myocytes.