[Synthesis of new derivatives of 3-benzyl-1,2-benzisothiazole and a study of analgesic activity in mice].
1983
: This paper describes the synthesis of 3-benzyl-1,2-benzisothiazole derivatives, structurally related to benzylisoquinolines, and their analgesic activity studied using writhing technique in the mouse. The presence of lipophilic substituents in position 3, 4 of the benzyl group give substances with analgesic activity, although their "potency" is lower than that shown by papaverine.
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