Amaranth oil reduces accumulation of 4-hydroxynonenal-histidine adducts in gastric mucosa and improves heart rate variability in duodenal peptic ulcer patients undergoing Helicobacter pylori eradication

H. pylori -induced oxidative stress (OS) in gastric mucosa (GM) is associated with accumulation of the 4-hydroxynonenal-histidine adducts (HNE)[1] and represents a milieu for chronic gastritis, duodenal peptic ulcer (DPU), gastric cancer and some extragastric diseases [2]. We aimed to test if a 4 week supplementation of amaranth seed oil (AO) influences accumulation of HNE in GM and heart rate variability (HRV) in H. pylori -positive DPU patients. 75 DPU patients were randomly split into two groups with standard medical treatment (n=39) and standard treatment plus 1 ml of AO per os, once a day, n=36). Clinical data and HRV records, endoscopy with biopsies from GM were performed before and after the treatment. Supplementation of AO significantly reduced accumulation of HNE in GM and increased HRV in DPU patients (p