Hypothyroidism may exacerbate valproate-related hyperammonemic delirium.
2016
Although it is well known that valproic acid (VPA) can induce hyperammonemia [1], few reports have been concerned with its relationship to hypothyroidism. Here we present a bipolar disorder patient with hypothyroidism (in fact, merely subclinical hypothyroidism) who experienced hyperammonemic delirium during VPA treatment.
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