In vivo Histomorphological Evaluation of Geopolymer-CarbonatedApatite Nanocomposites Implanted on Rabbit Tibiaat Early Bone Healing
2021
Dental implants have become more desirable treatment for replacing missing teeth.
The mechanical properties and biocompatibility of titanium and zirconia are excellent but they are
less bioactive. The chemical composition of the carbonate apatite is similar to enamel and dentin.
Geopolymers are inorganic polymers and they are similar to ceramics, they have an excellent mechanical
properties, bioactivity, biocompatibility.The purpose of this study is to assess the early bone healing
in osseointegration at geopolymer-carbonated apatite (CHA) nanocomposites. Methods: Geopolymer-
CHA nanocomposites with diameter of 3 mm and length of 6 mm is placed in tibia of eight male New
Zealand White rabbit whose body weight is 3 to 3.5 kg and 6 month ages. Experimental subjects were
randomly assigned to 2 groups for assessing the bone healing capability around samples to 14 and 28 days
histomorphologically. Wilcoxon test was performed and p <0.05 was considered significant, using Minitab
software version 13. Results: Granulation tissue, woven, and lamellar bone were analyzed. In the 14th
day revealed a reactive bone formation. Osteoblasts, osteoids, and osteocytes showed more mature and
woven bone became denser on the 28th day. Conclusion: Geopolymer-CHA nanocomposites could be
considered as a potential dental implant material from mechanical and biological properties point of view.
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