Study on processing technology and processing principles of atractrylodis macrocephalae rhizoma

Objective: To investigate the rule about changes on main active compositions of Atractrylodis Macrocephalae Rhizoma before and after being processed,and to explore its processing principle.Method: The HPLC method was employed to determine the content of atractrylone,atractrylodeⅠ,Ⅱ,Ⅲ and total volatile oil of Atractrylodis Macrocephalae Rhizoma with different processes.The processing principle before and after processing of Atractrylodis Macrocephalae Rhizoma was investigated.Result: Compared with Atractrylodis Macrocephalae Rhizoma,the contents of atractrylone in different processed products of Atractrylodis Macrocephalae Rhizoma were decreased by some extent.The lowest content was 0.33% in Atractrylodis Macrocephalae Rhizoma of stir-fried with dirt,reduced by 25.4%;the content of atractylenolide Ⅰ,Ⅲ were significantly increased,the highest content were 0.069% and 0.078% in Atractrylodis Macrocephalae Rhizoma of stir-fried with bran,respectively;the content of atractylenolide Ⅱ was increased slightly,the highest content was 0.066% in Atractrylodis Macrocephalae Rhizoma of stir-fried with dirt;the content of total volatile oil was significantly reduced,the lowest content was 0.64% in Atractrylodis Macrocephalae Rhizoma of stir-fried with dirt.Conclusion: The content of atractylon is significantly reduced after processing,which changed into atractrylodeⅠ,Ⅱ,Ⅲ by some extent,and improve the effective cure of Atractrylodis Macrocephala Rhizoma.