IDDF2020-ABS-0224 The risk of myocardial infarction in patients with inflammatory bowel disease: a meta-analysis

Background Systemic inflammation of inflammatory bowel disease (IBD) may increase the risk of cardiovascular events. Yet, the risk of myocardial infarction incidence in IBD patients is still unclear. We aim to investigate the risk of myocardial infarction in patients with ulcerative colitis (UC) or Crohn’s disease (CD). Methods We systematically searched for an observational study about IBD and myocardial infarction from PubMed, EBSCO, and Scopus up to August 2020. The inclusion criteria were the diagnosis of IBD preceding the incidence of myocardial infarction and survival study providing hazard ratio. Hazard ratio (HR) was calculated with 95% confidence interval (CI) while heterogeneity was assessed using the I2 statistics. The primary outcome was myocardial infarction incidence. Data from eligible cohort studies were pooled for effect estimates. Statistical analysis was performed using Review Manager software. Results We selected 4 eligible cohort survival studies for analysis. The pooled hazard ratio was 1.54 (95% CI 1.07–2.21; I2: 84%) for Crohn’s disease and 1.29 (95% CI 1.06–1.57; I2: 80) for Ulcerative Colitis (figure 1). High heterogeneity was attributed to the different follow-up periods and patient characteristics used in the pooled studies. The funnel plot was asymmetric, suggesting publication bias. Conclusions There was an association between IBD and the incidence of myocardial infarction. Further study is needed to confirm the results.