FOXP3 promotes tumor growth and metastasis by activating Wnt/β-catenin signaling pathway and EMT in non-small cell lung cancer

Shucai Yang,Yi Liu,Ming-Yue Li,Calvin S.H. Ng,Sheng-li Yang,Shanshan Wang,Chang Zou,Yujuan Dong,Jing Du,Xiang Long,Lizhong Liu,Innes Y.P. Wan,Tony Mok,Malcolm J. Underwood,George G. Chen

FOXP3 promotes tumor growth and metastasis by activating Wnt/β-catenin signaling pathway and EMT in non-small cell lung cancer

2017

Shucai Yang
Yi Liu
Ming-Yue Li
Calvin S.H. Ng
Sheng-li Yang
Shanshan Wang
Chang Zou
Yujuan Dong
Jing Du
Xiang Long
Lizhong Liu
Innes Y.P. Wan
Tony Mok
Malcolm J. Underwood
George G. Chen

Background The role of cancer cell FOXP3 in tumorigenesis is conflicting. We aimed to study FOXP3 expression and regulation, function and clinical implication in human non-small cell lung cancer (NSCLC).

Keywords:

FOXP3
Cancer cell
Cancer research
Biology
Carcinogenesis
Wnt signaling pathway
Metastasis
Lung cancer
Catenin
Signal transduction
Cyclin D1
Downregulation and upregulation
Cell growth

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