Nicotine clearance: genetic and environmental influences

The renal clearances of nicotine and cotinine, its proximate metabolite, vary considerably between individuals. This twin study looked at the influences of genetic and environmental factors on renal clearance. One hundred and ten monozygotic and 29 dizygotic healthy twin pairs with a mean age of 37.7 years were recruited. The group was predominantly female (69.9%) and Caucasian (76.1%). An intravenous infusion …