Failure of specific human tissue substrates to increase the sensitivity of indirect immunofluorescence testing in cicatricial pemphigoid.

: Indirect immunofluorescence testing was carried out on sera from 14 patients with cicatricial pemphigoid with use of both autologous and homologous human tissue substrates. The results were largely negative. The sensitivity of detection of circulating antibody is not increased with these substrates over that with animal tissue substrates.