Activity of the integrase inhibitor S/GSK1349572 in subjects with HIV exhibiting raltegravir resistance: week 24 results of the VIKING study (ING112961)

Background: S/GSK1349572(572) showed potent activity in Phase 2 studies in INI-naive HIV-infected subjects and limited cross-resistance to raltegravir (RAL) and elvitegravir in vitro. VIKING is an ongoing 24-week Phase 2b pilot study assessing 572 in subjects with RAL-resistant HIV. A good antiviral response during the functional monotherapy phase (through Day 11) of this pilot study was observed with a strong correlation between baseline susceptibility to 572 and response. Methods: 27 RAL-experienced, adult subjects, with screening plasma HIV-1 RNA ≥1000c/mL and genotypic resistance to RAL and ≥ 2 other ART classes, received 572 50mg QD in Cohort I while continuing their failing regimen (without RAL). At Day 11 the background regimen was optimised, where feasible, and 572 continued. The antiviral activity (primary end-point at Day 11), tolerability, safety and virology data through Week 24 of Cohort I are presented. A higher dose is being assessed. Results: At Baseline, subjects harboured viruses displaying high level resistance to RAL (median fold change in susceptibility [FC] 161, range: 0.57- >166) and low median FC to 572 (1.46, range: 0.55-35). Median (IQR) Baseline CD4+ and plasma HIV-1 RNA were 110 cells/mm3 (40, 230) and 4.47 log10c/mL (3.9, 4.9), respectively. Median number (range) of prior ART drugs was 18 (10, 23). Twenty one (78%) subjects achieved plasma HIV-1 RNA<400 c/mL (n=11) or ≥ 0.7 log10 c/mL decline (n=10) at Day 11 (primary end-point). Post Day 11, the optimised background regimen (OBR) phenotypic susceptibility score (PSS) was 0, 1 and ≥ 2 for 12 (44%), 7 (26%) and 8 (30%) subjects, respectively. 17 subjects continued therapy through Week 24 when 14/27 (52%) and 11/27 (41%) subjects achieved < 400 c/mL and < 50 c/mL, respectively by TLOVR. Response correlated with OBR PSS: 2/12 (17%) subjects with PSS =0, 4/7 (57%) with PSS=1 and 8/8 (100%) with PSS ≥2 achieved <400 c/mL at Week 24. Drug related AEs (any grade) were observed in 6 (22%) subjects. Two subjects with advanced AIDS died after withdrawal from study for SAEs (brain mass, non-Hodgkin's lymphoma with febrile bone marrow aplasia) unrelated to 572. Conclusions: Despite high level baseline resistance to RAL and the limited activity of the OBR co-administered with 572, the majority of subjects achieved < 400 c/mL at Week 24 with improved response rates in those receiving at least one active background ART. S/GSK1349572 was generally well tolerated in this advanced population. Supplement: Abstracts of the Tenth International Congress on Drug Therapy in HIV Infection http://www.biomedcentral.com/content/pdf/1758-2652-13-S4-info.pdf Conference: Tenth International Congress on Drug Therapy in HIV Infection 7-11 November 2010 Glasgow, UK (Published: 8 November 2010) doi:10.1186/1758-2652-13-S4-O51 Cite this article as: Eron et al.: Activity of the integrase inhibitor S/ GSK1349572 in subjects with HIV exhibiting raltegravir resistance: week 24 results of the VIKING study (ING112961). Journal of the International AIDS Society 2010 13(Suppl 4):O51. Full text: PubMed Central: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112867/