Evidence for a novel circulating alpha1 protein in tumour-bearing rats. Differentiation from acute phase alpha1 proteins and from alpha1 fetoprotein

1982 
Abstract It has been found in this study that the serum from rats bearing a transplanted dibenzanthracene-induced tumour ( RD 3 ), has a high concentration of alpha 1 proteins compared with normal rat serum. These alpha 1 proteins have been isolated by an immunoabsorption method and have been compared by immunological methods with the acute phase alpha 1 proteins isolated by the same method from the serum of rats presenting an inflammatory reaction. It has been found that the isolated RD 3 alpha 1 proteins were composed of two major proteins: one of these corresponded to an inflammatory protein, the alpha 1 -AP-globulin. The other may be a new protein, as it is absent from the serum of rats with an acute phase inflammatory reaction and nor does it correspond to alpha 1 feto-protein, a carcino-embryonic protein presenting the same electrophoretic mobility.
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