RATIO DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF OLMESARTAN MEDOXOMIL AND ATORVASTATIN CALCIUM IN THEIR COMBINED TABLET DOSAGE FORM Research Article

Simple, accurate, precise and sensitive spectrophotometric method for simultaneous estimation of Olmesartan medoxomil and Atorvastatin calcium in their combined tablet dosage form has been developed and validated. The ratio derivative spectrophotometry method involves measurement of first derivative amplitude of ratio spectra at 223 nm for Olmesartan medoxomil and 313 nm for Atorvastatin calcium as two wavelengths for estimation. Linearity is observed in the concentration range of 8-32 µg/ml and 4-16 µg/ml for Olmesartan medoxomil and Atorvastatin calcium respectively. The accuracy and precision were determined and found to comply with ICH guidelines. The method was found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of Olmesartan medoxomil and Atorvastatin calcium in their combined tablet dosage form.