Effects of Canarium schweinfurthii Oil Extract on Some Biochemical Indices on Indomethacin Induced Hepatotoxicity in Rats

The therapeutic effect of administration of oil extract of Canarium schweinfurthii on Indomethacin induced hepatotoxixity in rats was investigated. Twenty five albino rats were divided into five groups with five rats each. Group 1 served as baseline control, group 2 was administered with the oil extract only. Groups 3, 4 and 5 were administered 200mg/kg of indomethacin. Then, groups 4 and 5 were treated with 1mL/kg and 2mL/kg of oil extract respectively, while group 3 served as indomethacin negative control group. Among indices investigated were some biochemical and haematological parameters. At the end of the study, the results of our findings revealed that the level of haemaglobin and PCV significantly decreases (p Canarium schweinfurthii possesses some hepatocurative activity.