Chronic symptomatic unilateral anterior circulation stenosis or occlusion patients: a study of simultaneous cerebral blood flow and metabolism

1071 Objectives: Cerebral blood flow (CBF) and glucose metabolism are important and significant factors in ischemic cerebrovascular disease. The objective of this study was to analyze the CBF and metabolism using hybrid PET/MR to evaluate patients with chronic symptomatic unilateral internal carotid artery/middle cerebral artery steno-occlusive diseaseMethods: 40 patients with chronic symptomatic unilateral anterior circulation stenosis or occlusion were enrolled, including 30 male and 10 female patients with an average age of 52.78 ± 10.00 years. 18F-FDG PET, conventional MRI, DWI and ASL were performed on a hybrid PET/MR scanner (Signa, GE Healthcare). The blood flow decreased region, metabolism decreased region and common decreased region of each patient were calculated with the asymmetry index (AI). The CBF value measured by arterial spin labelling (ASL) and the standardized uptake value ratio (SUVR) measured by 18F-FDG PET were obtained, except for the infarct area and its contralateral side. Correlation analysis was used to identify the relationship between parameters and clinical neurological function score. A P-value of 0.05 was considered statistically significant. Results: There was no significant difference in SUVR value at the affected side between metabolism decreased region and common decreased region(P=0.409), while CBF in common decreased region was lower than that in blood flow decreased region(P<0.001). SUVR AI value and CBF AI value on the affected side were significantly higher than those in blood flow decreased region and metabolism decreased region(both P<0.001) (Table 1). Logistic regression analysis was used to demonstrated the correlation between clinical score and common decreased region (Fig. 1). Conclusion: With the abnormal cerebral blood flow and cerebral glucose metabolism information detected using 18F-FDG PET/MR, an objective imaging basis for early diagnosis and treatment could be provided for patients with chronic symptomatic unilateral ICA / MCA stenosis or occlusion.