Фотодинамическая терапия с фотосенсибилизаторами хлоринового ряда в лечении дисплазий шейки матки

Purpose. To assess the effectiveness of treatment of patients with precancerous diseases in the uterine cervix dysplasia using photodynamic technique (PDT) with photosensitizers «Radachlorine» and «Photoditazin». Materials and methods. 92 patients with uterine cervix dysplasia of various severity were examined: mild form (CIN I) - 30 (32.6%); moderate (CIN II) - 43 (46.7%) and severe (CIN III) - 19 (20.7%). Dysplasia was treated as follows: diathermoelectroconzation - 21 patient; radiotherapy - 17 patients; PDT with Photoditazin - 18 patients; PDT with Radachlorine - 36 patients. Results and discussion. Complete effect was seen in 34 patients out of 36 (94.4%) who had PDT with Radachlorine. No effect was noted in 2 out of 36 (5.6%) patients with CIN II (n-1) and CIN III (n-1). A patient with a moderate form of dysplasia had a repeated PDT course with a positive effect. A patient with CIN III who had ineffective criodestruction, laser vaporization for 7 years had DEC with an effect. A comparative assessment of complications after surgery has shown a high rate of complications after DEC (9.5%); after radiotherapy the rate of complications was by 1.5 times less (5.9%), while after PDT (2.8-5.6%) complications looked like a skin itching which did not need any medicamentous treatment. Conclusion. The obtained findings demonstrate that the techniques used in the study for treating uterine cervix dysplasia had a similar effectiveness (89-95%). PDT, which is quite a radical technique, did not cause damage to adjacent tissues, rough scarring and cervical canal stenosis; uterine cervix architectonics was preserved what is especially important for women who plan to get pregnant. After PDT epithelization has a considerably shorter phase; it also has less frequency of inflammatory reactions as well as postoperative and long-term complications as compared to DEC technique.