Migraine. Review of physiopathogeny and future alternative therapy

: This work examines recent discoveries in physiopathogenesis, focusing on the combination of sequential events involved in migraine origin. Recent facts concerning active intestinal peptide, substance P, histamine, HI and H3 receptors, and H3-receptor agonists, all neuromodulators having an intimate relations ship with migraine were examined. Present-day recommended treatment, with an efficacy of barely 70%, and reasons for its poor performance were described. The authors state that the future of migraine treatment should be directed toward the search for drugs that directly interact with the above-mentioned neuromodulators, thus offering patients a more efficacious treatment and fewer undesirable side-effects.