Observation of ultrastructure and ECP expression in nasal polyps

Objective:To observe the ultrastructural feature and ECP expression in nasal polyps,and aim to explore its role in the pathogenesis of CRSwNP.Method:5 CRSwNP,5 CRS and 5 control patients underwent sinus surgery were gathered to detect its ultrastructure and expression of ECP by in situ hybridization and electron microscopye technique.Result:Under electron microscopye,the eosinophilic cells in CRSwNP group increased,its membrane was intact but fold,the feature of pseudopodium,degranulation and cavitation were all found.The expression level of ECP mRNA was up-regulated.Conclusion:The findings suggest that eosinophilic infiltrate and ECP cytologic inflammation reactions may involve in the pathogenesis of CRSwNP.