Industrial production process of optically active, fluorine-containing alkyl ethylene oxide

Provided an industrial production process of optically active, fluorine-containing alkyl ethylene oxide. The A fluorine-containing alkyl chloromethyl ketone, by the action of enzymes with microorganisms or active having an activity of asymmetrically reducing the ketone, the optically active fluorine-containing alkyl chloromethyl alcohol with high optical purity yield it is possible to improve production. Subsequently, it is possible to obtain a fluorine-containing alkyl ethylene oxide by the action of a base to the alcohol. Production method of the present invention, industrial practice is easy.