Compound reserpine composition lyophilized tablet and preparation method thereof

2014 
The invention provides a compound reserpine composition lyophilized tablet and a preparation method thereof, and relates to the technical field of medicines and medicine production. The tablet is prepared from compound reserpine, starch and cane sugar, wherein starch and cane sugar are used as auxiliaries, common corn starch is subjected to heating treatment to improve the adhering and disintegrating effects of the starch in the tablet, so that the moldability of the tablet can be improved. The compound reserpine composition lyophilized tablet only needs two auxiliaries namely starch and cane sugar. According to the preparation method, a twice-cooling twice-heating lyophilizing process is adopted for the compound reserpine composition lyophilized tablet, the moldability of the tablet can be better by means of twice cooling and twice heating, the solubility of the tablet can be improved, and the bioavailability of the tablet can be improved; the tablet is capable of overcoming the defect of conventional compound reserpine tablets and reducing the types and usage of auxiliaries in the compound reserpine tablets, is high in solubility and high in bioavailability, and can be used for guaranteeing the curative effect and safety of clinical administration.
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