Синергидные нейропротекторные эффекты тиамина, пиридоксина и цианокобаламина в рамках протеома человека

Group B vitamins are characterized by neuroprotective effects. Mechanisms of action of synergistic combinations of various vitamins are insufficiently studied. In this study, proteins with activity or levels dependent on vitamins B 1 (thiamine), B 6 (pyridoxine) and B 12 (cyanocobalamin) were found in genomic and proteomic databases. Systems biology analysis showed that the thiamine is necessary for synthesis of ATP (glucose metabolism, lipid and branched chain amino acids), hemopoiesis and maintenance of neuronal structure. Pyridoxine-dependent proteins of the proteome are necessary for the metabolism of amino acids, ATP synthesis, synthesis of neurotransmitters and of neuronal membranes. Vitamin B 12 is needed for the metabolism of lipids, hemopoiesis and shows neuroprotective and neurotrophic effects. We identified numerous synergistic interactions of vitamins B 1 , B 6 , B 12 , at the molecular level, including the metabolism of amino acids, carbohydrates, lipids, forming structures of neurons, blood, ATP synthesis etc. The established mechanisms of vitamins B 1 , B 6 , B 12 synergy at the molecular level are of fundamental importance for neuroprotection and prevention of cerebrovascular disease.