Synthesis and biological screening of 2'-aryl/benzyl-2-aryl-4-methyl-4',5-bithiazolyls as possible anti-tubercular and antimicrobial agents.

Abstract A series of 2′-aryl/benzyl-2-aryl-4-methyl-4′,5-bithiazolyl derivatives, 25 – 64 were synthesized and evaluated for inhibitory activity against Mycobacterium smegmatis MC 2 155 strain and antimicrobial activities against four pathogenic bacteria Bacillus subtilis , Staphylococcus aureus , Escherichia coli and Proteus vulgaris . Among them, compounds 40 , 49 , 50 , and 54 exhibited moderate to good inhibition on the growth of the bacteria Mycobacterium smegmatis at the concentration of 30 μM. Compounds 26 , 40 , 44 , 54 and 56 exhibited moderate to good antibacterial activity. Compound 5-(2′-(4-fluorobenzyl)thiazol-4′-yl)-2-(4-fluorophenyl)-4-methyl-thiazole ( 54 ) exhibited both antitubercular as well as antimicrobial activity against all tested strains.