Propofol pharmacokinetics in patients with obstructive jaundice.

The effect of obstructive jaundice on the distribution and elimination of propofol was studied in 15 patients with obstructive jaundice (total serum bilirubin, TBL 17.1μmol.l ) and in 15 control patients (TBL 0.05). Half-times of the three phases ( T1/2 ,T1/2 ,T1/2 ) were also similar between both groups.We conclude that in patients with obstructive jaundice the pharmacokinetics of propofol are similar to those of patients without obstructive jaundice.