Antibacterial activity of β -Tricalcium phosphate containing nanosilver particles on periodontal Gram-negative pathogen

Abstract Introducction This research aimed to investigate the effect of antibacterial suspension containing TCP-β and nanosilver on these pathogens. Material and methods : Suspension containing concentrations of 4%, 2%, 1% and 0.1% was prepared with tricalcium phosphate and nanosilver. Two control suspensions for pure nanosilver and pure β-TCP were also prepared. The antibacterial activity of this suspension was investigated on two groups of bacteria, namely, P. intermedia and Aa in thioglycolate broth environment. Subsequently, the MIC was measured for each bacterium. Results The suspension containing β-TCP and nanosilver produced an antibacterial effect on P. intermedia and Aa . The effect of this solution on P. intermedia was greater than that on A .  actinomycetemcomitans . Moreover, the MICs (mg/mL) for P. intermedia and A .  actinomycetemcomitans were 1% and 0.1%, respectively. Conclusion Based on the results of this study adding nanosilver particles to β-TCP resulted in the antibacterial property of this substance. Specifically, reduced the growth rate of Aa and P. intermedia . Nanosilver can be used to reduce the risk of infection during or after regenerative surgery.