Mechanically-Induced Cytoskeletal Remodeling in 3D Cultures of Contractile Fibroblasts

Fibroblasts are responsible for collagen biosynthesis and organization in connective tissues, and play a role in regulation of epithelial differentiation, regulation of inflammation, and wound healing. Increasing evidence suggests that fibroblast might promote tumors by facilitating angiogenesis and cancer progression [1]. They are coupled mechanically to their fibrillar extra-cellular matrix, which can regulate cell behavior through its composition and mechanics.Copyright © 2010 by ASME