Immunohistochemical Analysis Of Brca1 And Acetyl-Histone H3 In Squamous Cell Carcinoma Of The Mobile Tongue

Abstract Objective : To evaluate the immunoexpression profiles of breast cancer 1 (BRCA1) and acetyl-histone H3 (AcH3) in squamous cell carcinoma of the mobile tongue (SCC-MT) and their correlation with epidemiological data and the histopathological grade of tumors. Study design : Incisional biopsies of 43 SCC-MT were submitted to immunohistochemistry for AcH3 and BRCA1. Samples were microscopically graded as well- differentiated (n = 21) or poorly differentiated (n = 22). Both groups were submitted to statistical analysis (p Results : Thirty-nine cases (91%) were positive for AcH3, but no difference was observed between the histological grading (p = 0.27). Positivity for BRCA1 was observed in all samples regardless of their cellular locations. Most cases in the poorly differentiated group presented with less than 10% nuclear staining (p Conclusion : AcH3 and BRCA1 were expressed in all samples. There was a significant decrease in cytoplasmic BRCA1 expression in the poorly differentiated group, suggesting BRCA1 as a possible prognostic marker for SCC-MT.