A Comparative Study on Ivermectin-Doxycycline and Hydroxychloroquine-Azithromycin Therapy on COVID-19 Patients

Objectives: We investigated the outcomes of Ivermectin-Doxycycline vs Hydroxychloroquine-Azithromycin combination therapy in mild to moderate COVID19 patients Methods: Patients were divided randomly into two groups: Ivermectin 200 mu gm/kg single dose + Doxycycline 100mg BID for ten days in group A, and Hydroxychloroquine 400mg for the first day, then 200mg BID for nine days + Azithromycin 500mg daily for five days in group B (Control group) RT-PCR for SARS-CoV-2 infection was repeated in all symptomatic patients on the second day onward without symptoms Repeat PCR was done every two days onward if the result found positive Time to the negative PCR and symptomatic recovery was measured for each group Results: All subjects in Group A reached a negative PCR, at a mean of 8 93 days, and reached symptomatic recovery, at a mean of 5 93 days, with 55 10% symptom-free by the fifth day In group B, 96 36% reached a negative PCR at a mean of 9 33 days and were symptoms-free at 6 99 days In group A 31 67% of patients expressed symptoms caused by medication, this was 46 43% in group B Conclusion: The combination therapy of Ivermectin-Doxycycline showed a trend towards superiority to the combination of Hydroxychloroquine-Azithromycin for mild to moderate COVID19 disease