Quantitative ultrasound measurements of bone strength in female adolescent idiopathic scoliosis patients

Methods This study was approved by the Human Research Ethic Committee of the School of Medicine, Jiaotong University, China. Eighty nine untreated female AIS patients were recruited in this study. The age range was from 10 to 16 years. Those who were using calcium supplements and those who had history of bone diseases were excluded from the study. The diagnoses of all AIS were confirmed by radiography based on American College of Radiology Guidelines and Recommendations. Cobb’s angles ranged from 10-52° (average 27.13°). The types of scoliosis included thoracic, lumbar, thoracolumbar and double curvatures. Patients’ menstrual conditions and family history were also taken in consideration. SOS was measured (by Sunlight omnisense) in the distal 1/3 of the radial bones. Data were compared to age and gender-matched norms (standard SOS value provided by Sunlight system). Results Radial SOS was significantly reduced in AIS patients compared to non-AIS subjects (P < 0.01); the radial SOS was also correlated to the age of the onset of menstrual cycle (lower in pre-menstrual cycle patients, 3626.92±124.35 vs. 3702.68±192.23, P<0.05). No significant correlations were found among the type of curvatures, the degree of Cobb’s angle, family history and bone SOS (P < 0.05).