Amorphous rotigotine (Rotigotine) transdermal system
2009
The present invention relates to a transdermal delivery device comprising a backing layer, the adhesive matrix layer and a release liner, the adhesive matrix layer comprises a substantially Lo is present in the adhesive matrix of a supersaturated concentration of rotigotine in amorphous form . The present invention also relates to a method for preparing adhesive matrix, said adhesive matrix comprising Luo substantially amorphous form present in a supersaturated concentration of rotigotine. The present invention further relates to a method to stabilize it during storage and reconstruction of transdermal drug manufacture amorphous metastable system, shipping and handling.
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