Effect of immobilization stress on the course of experimental influenza infection and the process of interferon formation

: The experimental data on the peculiar features of interferon production in C57BL/6 mice, infected with the lethal dose of influenza virus and simultaneously subjected to the action of a stress factor, are presented. Immobilization stress was found to exert pronounced influence on the interferon-producing system of the body, which was manifested by the appearance of alpha interferon in a titer of up to 1:80 in the blood of intact animals. 6-hour immobilization preceding infection did not accelerate the development of the lethal from of influenza infection, but sharply suppressed the viral induction of the synthesis of interferon.