The nucleotide sequence of a mouse renin-encoding gene, Ren-1d, and its upstream region

Abstract The renin-encoding genes have been cloned from high ( Ren-1 d , Ren-2 d )- and low ( Ren-1 d )-renin-producing strains of mice (DBA/2J and C57BL/10). Each of the genes is approx. 9.6kb in length and consists of nine exons and eight introns. The entire nucleotide sequence of the Ren-1 d gene has been determined and the 5'-flanking regions of the three genes, Ren-1 c , Ren-1 d and Ren-2 d , have been compared. The significance of several potential regulatory signals found in the DNA is discussed.