Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer

Jing Shan Lim,Alvaro Ibaseta,Marcus Fischer,Belinda Cancilla,Gilbert O’Young,Sandra Cristea,Vincent C. Luca,Dian Yang,Nadine S. Jahchan,Cécile Hamard,Martine Antoine,Marie Wislez,Christina S. Kong,Jennifer Cain,Yu-Wang Liu,Ann M. Kapoun,K. Christopher Garcia,Timothy Hoey,Christopher L. Murriel,Julien Sage

Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer

2017

In a mouse model of small-cell lung cancer and in human tumours, activation of the Notch pathway can lead to a cell fate switch of neuroendocrine cells to less proliferative non-neuroendocrine cells, generating intratumoural heterogeneity.

Keywords:

Cell
Notch signaling pathway
Immunology
Cell fate determination
Cancer research
Lung cancer
Tumour heterogeneity
Biology
Cellular differentiation
Small Cell Lung Carcinoma
Cell growth
Tumor microenvironment

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

191

Citations