Discovery of FR115092: A Novel Antinephritic Agent.

Abstract A series of dapsone-related 4-aminophenyl and 2-aminothiazolyl derivatives was prepared, and their antinephritic activity and blood toxicity were evaluated. 5-(2-Pyridylsulfonyl)-2-thiazolamine (FR115092, 26 ) was effective against two nephritis models, namely graft- versus -host disease (GVHD) and autoimmune W/BF 1 mice, and showed none of the blood toxicity observed with dapsone.