Voiding Function and Dysfunction, Bladder Physiology and Pharmacology, and Female Urology Re: Social Stress in Mice Induces Urinary Bladder Overactivity and Increases TPRV1 Channel-Dependent Afferent Nerve Activity

available at http://www.ncbi.nlm.nih.gov/pubmed/26224686 Editorial Comment: This is a very interesting article that addresses what I think is an immediate translational issue. During conscious cystometry in stressed mice a decreased intermicturition in- terval and reduced voided volume were observed, which were restored to normal by inhibition of TRPV1 channels. Using an ex vivo bladder preparation, the authors report that social stress increases afferent bladder nerve activity and that this increased activity can be significantly attenuated with TRPV1 channel inhibition, suggesting that this increase in afferent activity induced by social stress is due at least in part to TRPV1 activity. Stress has been reported to exacerbate symptoms of lower urinary tract dysfunction in overactive bladder, interstitial cystitis/bladder pain syndrome, bladder outlet obstruction, spinal cord injury and dysfunctional voiding.