[Relationship between AKAP95, cyclin E1, cyclin D1, and clinicopathological parameters in lung cancer tissue].

Objective To investigate the correlation between expression of A-kinase anchoring protein 95 (AKAP95) and protein expression of cyclin E1 and cyclin D1 in lung cancer tissue.Methods Fifty-one cases of lung cancer were included in the study.The protein expression of AKAP95,cyclin E1,and cyclin D1 were measured by immunohistochemistry.Results The protein expression of cyclin E1 in lung cancer tissues was significantly higher than that in paracancerous tissues (positive rate:75.56％ vs 20％,P＜0.01); its expression showed no relationship with histopathological type,lymph node metastasis,and cellular differentiation (P＞0.05).The protein expression of cyclin D1 in lung cancer tissues was higher than that in paracancerous tissues (positive rate:69.39％ vs 14.29％); its expression showed a significant relationship with histopathological type (P＜0.05).The expression of AKAP95 was correlated with the protein expression of cyclin E1 and cyclin D1 in lung cancer tissues (P＜0.01).Conclusion Cyclin E1 and cyclin D1 are highly expressed in lung cancer tissue,suggesting that they play an important role in the development and progression of lung cancer.The protein expression of cyclin E1 has no relationship with cellular differentiation,lymph node metastasis,and histopathological type of lung cancer,and the protein expression of cyclin D1 has a significant relationship with histopathological type.The expression of AKAP95 is correlated with the protein expression of cyclin E1 and cyclin D1 in lung cancer tissue. Key words: Lung cancer;  AKAP95;  Cyclin E1;  Cyclin D1;  Correlation analysis