Synthesis of novel 1,2,3-triazole/isoxazole functionalized 2H-Chromene derivatives and their cytotoxic activity.

Abstract A series of novel 2-(1,2,3-triazolylmethoxy) 5a – q and isoxazole tagged 6a – g 2 H -Chromene derivatives were prepared starting from salicylaldehyde and ethyl-4,4,4-trifluoroacetoacetate via cyclization to form ethyl 2-hydroxy-2-(trifluoromethyl)-2 H -Chromene-3-carboxylate 3 . Compound 3 on reaction with propargyl bromide resulted compound 4 and was independently reacted with aryl/alkyl azides and aryl aldoximes obtained 2-(1,2,3-triazolylmethoxy) and isoxazole tagged 2 H -Chromene derivatives 5a – q , 6a – i , respectively. Compounds 6 were further hydrolysed to acid derivatives 7a – g . All the products 5a – q , 6a – i , 7a – g were screened for cytotoxic activity against four human cancer cell lines and among all the compounds, 5f , 5g , 5l , 5q showed promising activity at