NIR-II Dye-based Multifunctional Telechelic Glycopolymers for NIR-IIa Fluorescence Imaging-guided Stimuli-responsive Chemo-Photothermal Combination Therapy

Optical imaging-guided chemo-photothermal combination therapy of cancers has attracted considerable attention due to its capacity for personalized, precision treatment and its synergistic chemo-photothermal therapeutic effect. However, it still encounters many barriers, including an unsatisfactory diagnostic accuracy, poor physiological stability, low drug loading and uncontrolled drug release. Here, we developed a NIR-II dye-based multifunctional telechelic glycopolymer (TTQ-TC-PFru) as drug-carrier and constructed stimuli-responsive PFru-BTZ-PBOB nanoparticles (NPs) to achieve the near-infrared IIa (NIR-IIa, 1300-1400 nm) fluorescence imaging (FI)-guided chemo-photothermal combination therapy of cancers. This multifunctional glycopolymer not only serves as the contrast agent for NIR-IIa FI but also functions as the photothermal agent for photothermal therapy (PTT). Meanwhile, the fructose polymer on TTQ-TC-PFru forms a stable boronic acid-catechol conjugate with the dipeptidyl boronic acid proteasome in...