Effects of local application of the ankaferd blood stopper on osseointegration in three different surface titanium implants

Abstract Objective Researchs of the effects of ankaferd blood stopper (ABS) on bone healing metabolism have revealed that it affects bone regeneration positively. The exact mechanism by which this positive effect on bone tissue metabolism is not known. The aim of this study is to biomechanic and biochemical analysis of the effects of the local ABS application on osseointegration of 3 different surfaced titanium implants. Material & Methods Spraque dawley rats were divided machined surfaced (MS) (n ​= ​10), sandblasted and large acid grid (SLA) (n ​= ​10) and resorbable blast material (RBM) (n ​= ​10) surfaced implants. ABS applied locally during the surgical application of the titanium implant before insertion in bone sockets. After 4 weeks experimental period the rats sacrificed and implants with surrounding bone tissues were removed to reverse torque analysis (Newton), blood samples collected to biochemical analysis (ALP, calcium, P) Results Biomechanic bone implant contact ratio detected higher in SLA surfaced implants compared with the RBM and controls (P ​ Conclusion According the biomechanical parameters ABS may be more effective in SLA and RBM surfaced implants when locally applied.