Method for producing pharmaceutical dimeticone
2012
The invention discloses a method for producing pharmaceutical dimeticone. The method comprises steps of stirring and mixing a mixture of octamethyl cyclotetrasiloxane and hexamethyl disiloxane completely in accordance with the mass ratio of (6-7) : (0.12-0.5), then placing the mixture to a gauge tank and heating the mixture in the gauge tank to a temperature of 90 DEG C to 95 DEG C; pressing the mixture to a catalytic reactor which contains a catalyst, subjecting the mixture to a circular reaction for 1-1.5 hours at the reaction temperature of 90 DEG C to 100 DEG C and obtaining crude dimeticone; pressing the crude dimeticone to a refined distillation still, heating the distillation still to a temperature of 190 DEG C to 230 DEG C, controlling the vacuum to be no more than -0.09 MPa, desorbing oligomer and low-boiling-point substances, conducting a refining operation for 4-6 hours, transferring materials to a cooling reactor after indexes of materials inside the distillation still, such as flash points, are qualified through a sampling test, cooling materials to be below 50 DEG C, performing pressure filtration and obtaining the pharmaceutical dimeticone. Quality indexes of the pharmaceutical dimeticone meet standards of 2010 version Chinese pharmacopoeia, the production cost is low and the economic benefit is obvious.
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