Metformin enhances nitric oxide production and diminishes Rho kinase activity in rats with hyperlipidemia
2014
Background
Rho kinase over-activation is associated with nitric oxide (NO) reduction and atherosclerosis. Metformin is favorable for endothelial function improvement and cardiovascular outcomes. Whether cardio-protective effect of metformin is associated with Rho kinase activity is unknown.
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