Tirotoksikoz nedenli erektil disfonksiyon üzerine sildenafil etkisinin histopatolojik olarak değerlendirilmesi

Aim: Thyrotoxicosis is a term that meets all clinical pictures caused by excessive thyroid hormone in peripheral blood and tissues. The thyrotoxicosis table negatively affects many organs and metabolic processes. One of them is the male reproductive system. In this experimental study, the histopathological evaluation of the effect of preventing dysfunction of sildenafil treatment in erectile dysfunction due to thyrotoxicosis is aimed. Materials and Methods: Four study groups were formed, each consisting of 8 rats. These experimental groups: The control group, Thyrotoxicosis (Experimental) group, Thyrotoxicosis+ sildenafil applied group (Treatment group) and Thyrotoxicosis+ sildenafil solvent applied group (Placebo). Male rats in the thyrotoxicosis group were injected with a dose of 0.2 mg / kg / day for 7 days with L-thyroxine. Following the application of L-thyroxine to the treatment group, sildenafil at a dose of 10 mg/kg/day was administered intraperitoneally for 24 days. When the experimental model was completed, 4% paraformaldehyde was taken for histochemical and immunohistochemical examinations. Routine immunohistochemical monitoring and staining were done, and all samples were evaluated under a light microscope. Results: In the subjects belonging to the experimental group, degeneration in the cavernous spaces, narrowing and loss of endothelial cells were determined. In the rats exposed to thyrotoxicosis in terms of fibroelastic connective tissue and smooth muscle distribution, there was a significant decrease in elastic fibers and smooth muscles and an increase in collagen fibers. In the treatment group, tunica albuginea, corpus cavernosum, venous sinuses, cavernosal trabecular smooth muscle and thin fibrous connective tissue were found to be close to normal histological structure. Diameters of cavernous bodies were found statistically significant (p <0.001). Similar differences were observed in fibrosis, degeneration, and contraction results in cavernous structures. According to the bilateral analysis, while the differences between the control-treatment and experimental-placebo groups were not statistically significant, all other binary differences were found significant (p <0.05). In terms of peripheral nerve degeneration, only the control group's differences with the experimental and placebo groups were found to be significant (p <0.05). Conclusion: It has been determined that the experimental model of thyrotoxicosis caused histological damage in penile cavernosae. It has been provided that exogenous sildenafil application reduces histopathological degenerative effects.