Toxicity of Copper Chlorophyllin-Upconversion nano-composites in rat

Traditional fluorophores for fluorescence medical imaging are associated with downconversion phenomenon upon ultraviolet stimulation and lead to many obstacles. Nevertheless, a recent categorization of inorganic fluorescent nano-particle was produced in order to prevent these limitations such as: the upconversion nano-particles (UCNPs). So that, our results suggested that: Photosensitizer (PSs) for example chlorophyll types are the best used because they come from natural sources and have a several features better than other Ps. On the other hand, the potential toxicity and biocompatibility of UCNPs are in connection with their biomedical methodologies. Bear in mind that, UCNPs cannot be rapidly involved in biological environment. Above all, work out the good manners of UCNPs in biological systems as well as overcome toxicity to pave the way to utilize this type of nano-particles in medical methodologies recently.