Transient mixed hematopoietic chimerism in dogs given thymic irradiation before and pharmacologic immunosuppression after marrow transplantation

We used postgrafting immunosuppression with mycophenolate mofetil (MMF) and cyclosporine (CSP) to control both graft-versus-host and host-versus-graft reactions in a canine model of dog leukocyte antigen (DLA)–identical littermate marrow transplants. This way, the single pretransplantation dose of