Antibody Subunit LC-MS Analysis for Pharmacokinetic and Biotransformation Determination from In-Life Studies for Complex Biotherapeutics

John F. Kellie,Kristen E. Pannullo,Yinghe Brenda Li,Kristy J Fraley,Andrew P. Mayer,Caroline J. Sychterz,Matthew Szapacs,Molly Z Karlinsey

Antibody Subunit LC-MS Analysis for Pharmacokinetic and Biotransformation Determination from In-Life Studies for Complex Biotherapeutics

2020

John F. Kellie
Kristen E. Pannullo
Yinghe Brenda Li
Kristy J Fraley
Andrew P. Mayer
Caroline J. Sychterz
Matthew Szapacs
Molly Z Karlinsey

Complex biotherapeutics present challenges from drug discovery, screening, and development perspectives. While monoclonal antibody drugs are not monitored for metabolites in the same manner as smal...

Keywords:

Liquid chromatography–mass spectrometry
Protein subunit
Monoclonal antibody
Biotransformation
Antibody
Chemistry
Pharmacokinetics
Chromatography
Drug discovery

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