Obsessive Compulsive Disorder and Multiple Sclerosis: Three Cases

4 OZET: Obsesif kompulsif bozukluk ve multipl skleroz: Uc olgu Obsesif kompulsif bozukluk (OKB) ile ilgili cok say›da cal›flma bulunmas›na ramen patogenezi ile ilgili az fley bilinmektedir. Son y›llarda immunolojik mekanizmalar ileri surulmufltur. OKB, streptokok enfeksiyonlar› ile iliflkilendirilen tikler, hareket bozukluklar›, emosyonel labilite ve obsesif kompulsif davran›fllardan oluflan pediyatrik otoimmun noropsikiyatrik sendrom (PANDAS) kapsam›nda tan›mlanm›flt›r. OKB ve otoimmun hastal›klar aras›ndaki iliflki yeni bir araflt›rma alan› oluflturacakt›r. Bu nedenle, otoimmun hastal›klar›n bir prototipi olan multipl skleroz (MS) ile OKB birliktelii dikkate deerdir. Bu bildiride MS ile birlikte gorulen uc OKB olgusu ilgili yaz›n balam›nda tart›fl›lm›flt›r. Tum hastalarda OKB, MS'den once bafllam›flt›r. Hastalarda streptokok enfeksiyonu, tik veya hareket bozukluu oykusu yoktu ve immunoterapi suresince OKB belirtilerinde duzelme tan›mlam›yorlard›. ABSTRACT: Obsessive compulsive disorder and multiple sclerosis: three cases Despite the presence of a large body of studies, little is known about the pathogenesis of obsessive compulsive disorder (OCD). Immunological mechanisms have been suggested in recent years. OCD has been described in the context of the pediatric autoimmune neuropsychiatric syndrome (PANDAS), characterized by tics, dyskinesia, emotional lability and obsessive-compulsive behaviors, associated with streptococcal infections. The association of OCD with autoimmune diseases promises to constitute a new research area. Thus, comorbidity of OCD with a prototypic autoimmune disease, multiplee sclerosis (MS), would be notable. In this report we present three OCD cases with comorbid MS and discuss our cases in the light of relevant literature. Obsessive Compulsive Disorder preceded MS in all patients. The patients reported no streptococcal infection, tic disorder or movement disorder history and had no improvement of OCD during immunotherapy.