Magnetic solid-phase extraction based on zirconium-based metal-organic frameworks for simultaneous enantiomeric determination of eight chiral pesticides in water and fruit juices.

Abstract A novel multi-residue method, magnetic solid-phase extraction combined with LC–MS/MS, was proposed for simultaneous enantiomeric determination of eight chiral pesticides in water and fruit juices. Fe3O4@C@UiO-66 was firstly used to extract and enrich pesticides, showing excellent adsorption capacity, which was proved by adsorption kinetic and thermodynamic experiments. Multiple extraction parameters were optimized by Plackett-Burman and Box-Behnken design. Under optimized conditions, good linearity (1.0–200 ng L−1, R2 ≥ 0.9953) for all analytes, detection limits (0.10 to 0.35 ng L−1), quantitation limits (0.35 to 1.00 ng L−1), recoveries (83.68–95.99%), and precision (intra-day RSD ≤ 7.06%, inter-day RSD ≤ 9.40%) were obtained, meeting the requirements of pesticides residues analysis. It is worth mentioning that eight chiral pesticides can be separated quickly within 19 min. The above results indicate that the proposed method with satisfactory sensitivity and accuracy has the potential for routine analysis of chiral pesticide residues in aqueous samples.