Prediction of prognosis for melanoma cancer

A method for determining the prognosis of melanoma in a patient, the method comprising: (i) determining the expression level of a prognostic marker of melanoma (MPM) is a protein factor 8 Globule milk fat-EGF ( MFGE8), or a prognostic signature comprising two or more MMPs, at least one of which is MFGE8 in a sample of the tumor melanoma patient, (ii) applying a predictive model, established by applying a predictive method expression levels of the MPM or prognostic signature in tumor samples with good and poor prognosis, (iii) establish a prognosis.